Diamond Light Source
Beamline VMXi - Versatile Macromolecular Crystallography (in situ)

The Versatile Macromolecular X-tallography in-situ(VMXi) beamline is an entirely automated facility for characterisation of, and data collection directly from, crystallisation experiments in situ.

There are four key advantages of in situ diffraction:
  • Experiments can be carried out without any manipulation of individual crystals, thus preserving the crystal integrity.
  • It provides immediate feedback on the diffraction, crystal quality and, in many cases, unit-cell parameters, space group, even in the case of micro-crystals (2-5 μm).
  • The method can be fully automated with high reliability.
  • It provides a route for data collection from crystals that consistently lose all diffraction when conventionally harvested, or else are hazardous and may not be harvested for safety reasons.

Diamond User Office
  • Crystallography
  • Crystallography (biological macromolecules)
Emission or Reflection
  • X-ray fluorescence (XRF)
control/Data analysis
Control Software Type
  • ISPyB
Data Output Type
  • Images
Data Output Format
  • hdf5