MASSIF-1 is a world leading unique facility for the high throughput, fully automatic characterisation and data collection of macromolecular crystals. The new service is not designed to replace user visits to the synchrotron, but rather to do the hard work of screening crystals or collecting routine data sets through the night, freeing researchers to spend more time on challenging data collection problems and study of the underlying biology.


The software routines used on MASSIF-1 and the beamline itself have been described in the following publications:


Svensson, O., Monaco, S., Popov, A. N., Nurizzo, D. & Bowler, M. W. (2015). Fully automatic characterization and data collection from crystals of biological macromolecules, Acta Cryst. D71, 1757-1767

Bowler M.W., Nurizzo, D., (2015) MASSIF-1: A beamline dedicated to the fully automatic characterisation and data collection from crystals of biological macromolecules J. Sync. Rad. 22, 1540-1547

Svensson, O., Gilski, M., Nurizzo, D. & Bowler, M. W. (2018). Multi-position data collection and dynamic beam sizing: recent improvements to the automatic data-collection algorithms on MASSIF-1, Acta Cryst. D74, 433-440,

Bowler, M.W., Svensson, O. & Nurizzo, D. (2016): Fully automatic macromolecular crystallography: the impact of MASSIF-1 on the optimum acquisition and quality of data, Cryst. Rev., 22, 233–249

Nurizzo, D., Bowler M.W., Caserotto, H., Dobias, F., Giraud, T., Surr, J., Guichard, N., Papp, G., Guijarro, M., Mueller-Dieckmann, C., Flot, D., McSweeney, S. Cipriani, F, Theveneau, P. and Leonard, G. (2016) RoboDiff: combining a sample changer and goniometer for highly automated macromolecular crystallography experiments Acta Cryst D 72, 966-975,

Beamline Energy Range
12.8 [eV]
Max Flux On Sample
6 * 1012 [ph/s] @ 12.8 [eV]
Spot Size On Sample Hor
10 - 200 [um]
Spot Size On Sample Vert
10 - 200 [um]
Matthew BOWLER
  • Crystallography (biological macromolecules)
Life Sciences & Biotech
  • Medicine
  • Molecular and cellular biology
control/Data analysis
Control Software Type
Data Output Type
  • cbf images
Data Output Format
  • cbf
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